Description

Dapagliflozin & Metformin Hydrochloride Extended-Release Tablets are combination medications used to help control blood sugar levels in adults with type 2 diabetes mellitus. They are typically used alongside diet and exercise and may be combined with other diabetes medications.

Components:
Dapagliflozin

Class: SGLT2 (Sodium-Glucose Cotransporter 2) inhibitor

Mechanism: Increases the excretion of glucose in urine by preventing its reabsorption in the kidneys.

Metformin Hydrochloride (Extended-Release)

Class: Biguanide

Mechanism: Decreases hepatic glucose production and improves insulin sensitivity.

Indications:
Type 2 diabetes mellitus (as an adjunct to diet and exercise)

May help in weight loss and blood pressure reduction (dapagliflozin-related effects)

Common Brand Names (may vary by country):
Xigduo XR (commonly used in the U.S.)

Typical Dosage:
Varies by individual; commonly taken once daily with food (usually in the morning).

Tablets are extended-release and should not be crushed or chewed.

Side Effects:
Common:

Urinary tract infections

Genital infections (e.g., yeast infections)

Nausea, diarrhea

Headache

Serious (but rare):

Lactic acidosis (linked to metformin)

Dehydration or low blood pressure (due to fluid loss with dapagliflozin)

Ketoacidosis

Kidney problems

Warnings & Precautions:
Not for use in type 1 diabetes or diabetic ketoacidosis

Monitor kidney function regularly

Avoid excessive alcohol use

Risk of lactic acidosis (metformin) especially in patients with poor kidney function

Important Patient Tips:
Stay hydrated.

Inform your doctor about all other medications.

Monitor blood sugar regularly

Take it with food to minimize stomach upset